Thrombosis is a complex disease with very high genetic component. Inherited thrombophilia predisposes an individual to events associated with cardiovascular disease. This test genotypes 3 of the most heritable mutations used for diagnosing patients with suspected thrombophilia:
Factor V Leiden - the Leiden variant increases risk for spontaneous and/or recurrent venous thromboembolism.
Prothrombin 20210 – the variant enhances prothrombin production, increasing a person’s risk for spontaneous and/or recurrent venous thromboembolism.
MTHFR677 – the variant reduces homocysteine metabolism and increases the risk for cardiovascular disease.
A single blood sample is required to test all 3 mutations. DNA is extracted and mutation analysis is performed. The test is available through your Ordering Physician. A copy of the requisition is available below.
Tests available: